Micky van de Ven became the first backline player to score two goals in a Premier League match for Tottenham since Jan Vertonghen in spring 2013.
Match summary
The Spurs defender nods home twice in opening period
Everton's defender has equalizer disallowed after VAR review
Pape Matar Sarr scores final goal in 89th minute
This loss is Everton's first at their new ground
Micky van de Ven found the net twice as Spurs extended their winning streak on the road in the Premier League and handed Everton their first defeat at their new home.
The Toffees were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having left Goodison Park behind after more than a century at the conclusion of the previous campaign.
But Tottenham's leader the Dutchman pounced on two occasions from set-pieces in the first half to put their impressive record at risk, and they were failed to mount a comeback before the midfielder - set up by former Toffees attacker the Brazilian - nodded in a third to put the game to bed.
The Everton defender believed he had levelled the scores five minutes after Van de Ven's opener, glancing a bullet header past the Spurs keeper from an Everton corner.
The Portuguese striker, in the meantime, failed to convert a number of opportunities, while the Italian goalkeeper made a series of fine stops to guarantee Tottenham went five matches on the road unbeaten in the Premier League.
But the video assistant referee intervened, instructing the match official to check the goal on the pitchside monitor and the official decided that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.
This victory elevates Thomas Frank's side into third place in the division, five points off north London rivals and leaders Arsenal.
Everton stay 14th and sit half a dozen points clear of the relegation zone.
After a drab weekday display in the Champions League against Monaco, where they mustered a mere attempts on target, the manager opted for Randal Kolo Muani in attack instead of ex-Everton forward the Brazilian.
The summer signing was failed to influence the game before being substituted for Richarlison after an hour on the pitch, but it emerged he wasn't needed in the final outcome.
Defender Van de Ven transformed into an attacking force to be feared.
Tottenham's opening strike came from a cleverly executed set-piece play, with the midfielder directing the ball back across the six-yard box for an unmarked the defender to head home.
And Ven de Ven - filling in as captain in the Argentine's unavailability - notched his next goal in added time as he rose above Jordan Pickford to nod in.
The Dutchman was equally impressive in defence, partnering effectively with his defensive colleague as the duo dealt excellently with the numerous deliveries sent their way by Everton.
Everton's new home had been a happy hunting ground, but it appears the novelty may have worn off somewhat and fans headed to the gates after the midfielder's third for Tottenham.
The break in the team's unbeaten home run won't be a massive concern for the manager, but their striker situation are.
The forward and the other striker - the Everton's two established centre-forwards - had scored only a single goal combined before Sunday's outing.
And they were failed to add to that miserable record on a damp and dreary evening on in Liverpool.
The striker's form was epitomized when he chose to overhead kick a golden opportunity from close range, despite having space and time to reposition for a simpler shot that would have tested the keeper.
Barry, too, was unable to influence the game after replacing Beto in the second half.
It wasn't for a shortage of chance. The majority of Everton's offensive moves came through Grealish and the forward, who relentlessly whipped dangerous balls into the Tottenham box.
The Toffees: Moyes' men head to Sunderland in the top flight on Monday, 3 November at 20:00 GMT.
Spurs: Spurs travel to Newcastle's ground on late October for their next round League Cup match against the Magpies.
A passionate gaming enthusiast and writer with over 5 years of experience in reviewing online casinos and slot games.
Mrs. Brenda Steele
Mrs. Brenda Steele